GLP-1 PowerPlug explained: what the Ring, CGM and blood tests show while you are on a GLP-1

What is GLP-1 PowerPlug?

The Ultrahuman Ring's GLP-1 PowerPlug tracks how your readings change while you're on a GLP-1 medicine.

Follow-up on a GLP-1 medicine usually rests on weight, which is checked at appointments months apart.

But a shift in heart rate, sleep, or glucose isn't usually part of that follow-up, so the PowerPlug is designed to help you follow changes between clinical appointments.

How the GLP-1 PowerPlug works

The GLP-1 PowerPlug analyzes heart rate variability (HRV), resting heart rate, sleep, and skin temperature. It also adds your glucose readings if you wear an Ultrahuman CGM, and your blood results if you use Blood Vision.

You log your dose, any symptoms, your weight and, if you track it, your muscle mass.

Each time your dose steps up, the PowerPlug sets your Ring readings from the week after against the week before, so you see a change measured against yourself.

Safety Radar, the PowerPlug's safety monitor, draws on your readings, your results, and your logs, and checks again whenever something new arrives, whether that is a logged dose or a night's sleep.

Safety Radar rates the changes in your data on five levels: Good, Attention, Caution, Warning and Critical. Follow the action shown on the card. Seek care for concerning symptoms even if the app shows no alert.

Why GLP-1 PowerPlug works this way

We built the PowerPlug because follow-up on a GLP-1 medicine usually rests on weight, checked at appointments months apart. A scale cannot show a shift in your heart rate, your sleep, or your glucose.

One man's readings began shifting in his first week on the medicine, which we describe in a case study comparing his weeks on it with his own weeks beforehand. It is an Ultrahuman Science white paper and it has not been peer reviewed. One person cannot tell you what will happen to you.

Some of the weight you lose is lean mass, which includes muscle, so the PowerPlug lets you log muscle mass beside your weight.

It draws on three sources: heart and sleep from the Ring, glucose from a CGM, and the markers in Blood Vision that only a blood test can measure.

What the research says

Heart rate tends to rise on these medicines. In a 2026 review of 12 studies in adults without diabetes who were overweight or had obesity, heart rate ran about 3.5 beats per minute higher than on a placebo. That pooled figure covers a wide spread between drugs and doses, from around half a beat per minute for one drug and dose up to over nine for another.

HRV findings are less consistent. In a trial of 27 adults with newly diagnosed type 2 diabetes and coronary artery disease, 24-hour HRV fell, and average heart rate rose by about 8 beats per minute over 12 weeks on a GLP-1 medicine, compared with the same stretch on a placebo. The rise was clearest at night. A meta-analysis of trials in people with diabetes also found a rise in heart rate, with no clear change in HRV.

A 2025 review of 22 trials covering 2,258 participants estimated that about a quarter of the weight lost on GLP-1 medicines and related treatments was lean mass, though the share differed between medicines.

What Ultrahuman's data shows

We looked at 862 members who logged GLP-1 use. They walked less in the six weeks after adding the GLP-1 PowerPlug than in the six weeks before: 6,345 steps a day on average, down to 5,956, or 389 steps fewer.

We compared each member only with themselves, with no group of members who were not taking the medicine, so we cannot say the medicine caused the drop.

The day someone added the PowerPlug is only an estimate of the day they started the medicine, and some had started earlier, so this does not describe what happened from the real starting point.

Changes in how often people wore the Ring, in their symptoms, and in their routines may all have contributed.

How to read GLP-1 PowerPlug's guidance

Read each change against your own baseline, from before you started or before your last dose change, and compare weekly averages instead of single nights.

A small rise in resting heart rate is common on GLP-1 medicines. If your daily steps fall, look at what else changed that week before you put it down to the medicine. Illness, alcohol, hard training, and travel move the same readings.

Contact your doctor if your resting heart rate stays higher than usual, or if you notice a racing heartbeat at rest. Do not wait several weeks to see whether it settles. Seek urgent medical care for persistent severe abdominal pain, inability to keep fluids down, or a fast heartbeat with significant dizziness. Call emergency services for chest pain, fainting or severe breathlessness. Do not wait for an app alert.

If you have symptoms of low blood sugar, such as shakiness or sweating, follow the hypoglycemia plan agreed with your clinician and seek advice. Low glucose is more likely when these medicines are taken with insulin or certain other diabetes medicines. Confusion, seizures or loss of consciousness need emergency help.

What GLP-1 PowerPlug can't tell you

GLP-1 PowerPlug shows what changed in your readings. It cannot tell you why, and it cannot separate the medicine from eating less, sleeping differently, or a change in your routine.

The Ring does not measure muscle or body fat, so the PowerPlug works from the body-composition numbers you log. A scale estimate is not the same thing as a clinical assessment of muscle mass or strength.

The PowerPlug does not diagnose you and it does not decide anything about your medicine. Ultrahuman does not prescribe or supply medicines, and whether to start, change, or stop one is your doctor's decision.